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KMID : 1007520110200030841
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Food Science and Biotechnology
2011 Volume.20 No. 3 p.841 ~ p.844
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Anti-allergic Effect of Low Molecular Weight β-Glucan Prepared by γ-Irradiation
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Sung Nak-Yun
Choi Jong-Il
Yoon Yo-Han
Lee Soo-Young
Byun Myung-Woo
Hwang Yeoung-Jung
Zubaidah Irawati Koenari
Lee Ju-Woon
Kim Jae-Hun
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Abstract
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This study evaluated the anti-allergic effect of low molecular weight β-glucan (25 kDa) degraded by γ- irradiation. Allergy was induced in mouse models administrated with γ-irradiated low molecular weight and non-irradiated high molecular weight β-glucan, respectively, for 7 days. However, only the mice treated with low molecular weight β-glucan had a significantly decreased the total serum IgE and ovalbumin specific-IgE levels, and significantly increased Th 1 cytokine expression compared to only allergy induced mice. The allergic responses could be reduced by low molecular weight β-glucan treated γ- irradiation through the increased expression of Th 1 response and decreased expression of total IgE and antigen specific IgE.
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KEYWORD
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allergy, β-glucan, low molecular weight, cytokine
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